Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase

Authors

  • Tehmina Nafees Sonia Khan NIBD
  • Tariq Masood North West Medical College,Peshawar
  • Zara tul ain Bashir National Institute of Blood Diseases and Bone Marrow Transplantation,karachi
  • Tasneem Farzana National Institute of Blood Diseases and Bone Marrow Transplantation,karachi
  • Abdul Sattar National Institute of Blood Diseases and Bone Marrow Transplantation,karachi
  • Tahir Shamsi National Institute of Blood Diseases and Bone Marrow Transplantation,karachi

DOI:

https://doi.org/10.38106/LMRJ.2022.4.2-03

Keywords:

Hemostasis, Thrombotic markers , Fibrinolysis, pre and post induction chemotherapy, Leukemia

Abstract

This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). A total of 110 diagnosed acute leukemia patients and 40 normal individuals were enrolled in the study. Questionnaire were filled and patients’ blood specimens were collected before the commencement and post induction chemotherapy. Prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor antigen (vWF Ag), fibrinogen level, factor VIIIc (FVIIIc), D-Dimers, fibrinogen degradation products (FDPs), anti-thrombin III (AT), lupus anticoagulant (LA), protein C (PC), protein S and diluted russel viper venom test (DRVVT) were conducted in all the participants. A significant rise was identified in post-induction levels of PT, aPTT, vWF Ag, fibrinogen and factor VIII in acute leukemia patients. Analysis of fibrinolytic markers indicated increased D-Dimers and plasminogen levels while the levels of alpha 2 anti-plasmin were reduced in pretreated patients. Thrombotic markers’ assessment showed increased levels of AT and LA while decreased level of PC in pretreated acute leukemia patients. It was concluded that remission induction chemotherapy, in acute leukemia patients, significantly affects the coagulation, fibrinolytic and thrombotic parameters.

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Published

2022-06-29

How to Cite

Khan, T. N. S., Masood, T. ., Bashir, Z. tul ain, Farzana, T., Sattar, A., & Shamsi, T. (2022). Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase. LIAQUAT MEDICAL RESEARCH JOURNAL, 4(2). https://doi.org/10.38106/LMRJ.2022.4.2-03

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