Unusual Presentation of Factor XII Deficiency with Bleeding: A Rare Case Report

LMRJ

Abstract

Factor XII (FXII) is a coagulation protein involved in the initiation of coagulation
via contact activation system. Congenital FXII deficiency is a rare, asymptomatic
disorder, associated with an isolated prolonged activated partial thromboplastin
time (APTT). FXII deficiency is not commonly associated with any bleeding
symptom except for a few cases presenting with occasional minor bleeds, which
do not require treatment. Instead, a few literature reports suggest an increased
incidence of various thromboembolic events in these patients. We report a rare
occurrence of FXII deficiency presenting with severe bleeding symptoms.