Physicochemical Analysis and Cost Comparison of Different Local and Multinational Brands of Sitagliptin Available in Pakistan

Abstract

The main objective of this study was to determine that various generic sitagliptin products from local and multinational brands competing in the local market are pharmaceutical equivalents. A physicochemical comparison was conducted on local and international brands of sitagliptin tablets gathered from local drug outlets of Hyderabad, Pakistan. A total of 5 sitagliptin brands were taken and globally accepted in-vitro tests were performed at Industrial pharmacy laboratory of Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh, Jamshoro Pakistan, during period August 2021 to August 2022. All the sitagliptin products obtained from local market were fulfilling the quality standards required by BP for tests of weight uniformity, diameter, thickness, hardness, friability, disintegration, and World Health Organization (WHO) standards for tests of dissolution and content uniformity/assay. All sitagliptin generics from different local and multinational manufacturing companies are pharmaceutical equivalents and may be prescribed as an alternate to each other.